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Abstract #3353

Patient-specific hyperdirect pathway activation in DBS for Parkinson's disease

Alba Segura Amil1,2, T.A. Khoa Nguyen1,2, Andreas Nowacki1, and Claudio Pollo1
1Department of Neurosurgery, University Hospital Bern, Bern, Switzerland, 2ARTORG Center for Biomedical Engineering, University of Bern, Bern, Switzerland


Deep brain stimulation is an effective treatment in advanced Parkinson’s disease. The aim of the study was to determine activation thresholds for the hyperdirect pathway and corticospinal tract to control motor symptoms and avoid the appearance of side effects. Patient-specific whole brain tractograpy, DBS leads reconstruction, and generation of volumes of tissue activated were performed in 20 Parkinson patients. The activation threshold for the hyperdirect pathway was 60%, and for the corticospinal was 4%. For newly generated volumes of tissue activated, the average prediction error for the hyperdirect pathway was 1 mA and for the corticospinal tract was 1.5 mA.

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