Deep brain stimulation is an effective treatment in advanced Parkinson’s disease. The aim of the study was to determine activation thresholds for the hyperdirect pathway and corticospinal tract to control motor symptoms and avoid the appearance of side effects. Patient-specific whole brain tractograpy, DBS leads reconstruction, and generation of volumes of tissue activated were performed in 20 Parkinson patients. The activation threshold for the hyperdirect pathway was 60%, and for the corticospinal was 4%. For newly generated volumes of tissue activated, the average prediction error for the hyperdirect pathway was 1 mA and for the corticospinal tract was 1.5 mA.