Meeting Banner
Abstract #3354

Comparison of high-resolution quantitative peripheral nerve imaging in CMT1A and healthy controls using Double-Echo in Steady-State at 7 Tesla

Bragi Sveinsson1,2, Robert Barry1,2,3, Olivia Rowe1,2, Jason Stockmann1,2, Daniel Park1, Peter Lally4, Matthew S Rosen1,2,5, and Reza Sadjadi6
1Radiology, A. A. Martinos Center, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Health Sciences and Technology, Cambridge, MA, United States, 4Brain Sciences, Imperial College London, London, United Kingdom, 5Physics, Harvard University, Cambridge, MA, United States, 6Neurology, Massachusetts General Hospital, Boston, MA, United States


The ability to estimate neurological disease progression based on objective quantitative measurements could be of great value for assessing treatment efficacy. Here, we demonstrate the feasibility of acquiring high-resolution anatomic and quantitative images at 7T in the sciatic, tibial, and fibular nerves, allowing quantitative assessment of individual fascicles. We also measure the quantities of fascicle cross-sectional area, T2, ADC, and fat fraction for CMT1A patients and healthy controls and investigate any between-group differences.

This abstract and the presentation materials are available to members only; a login is required.

Join Here