Abstract #3354

Comparison of high-resolution quantitative peripheral nerve imaging in CMT1A and healthy controls using Double-Echo in Steady-State at 7 Tesla

Bragi Sveinsson^1,2, Robert Barry^1,2,3, Olivia Rowe^1,2, Jason Stockmann^1,2, Daniel Park¹, Peter Lally⁴, Matthew S Rosen^1,2,5, and Reza Sadjadi⁶

¹Radiology, A. A. Martinos Center, Massachusetts General Hospital, Boston, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Harvard-MIT Health Sciences and Technology, Cambridge, MA, United States, ⁴Brain Sciences, Imperial College London, London, United Kingdom, ⁵Physics, Harvard University, Cambridge, MA, United States, ⁶Neurology, Massachusetts General Hospital, Boston, MA, United States

Synopsis

The ability to estimate neurological disease progression based on objective quantitative measurements could be of great value for assessing treatment efficacy. Here, we demonstrate the feasibility of acquiring high-resolution anatomic and quantitative images at 7T in the sciatic, tibial, and fibular nerves, allowing quantitative assessment of individual fascicles. We also measure the quantities of fascicle cross-sectional area, T2, ADC, and fat fraction for CMT1A patients and healthy controls and investigate any between-group differences.

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