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Abstract #3356

Aberrant Structural Brain Network Hierarchy in Trigeminal neuralgia

Yael Jacob1, Gaurav Verma1, Judy Alper1, Bradley Delman1, Alan Seifert1, Raj Shrivastava1, and Priti Balchandani1
1Icahn School of Medicine at Mount Sinai, New York, NY, United States


Trigeminal neuralgia (TN) is a physically and mentally incapacitating disorder characterized by extreme, sporadic, sudden facial pain. TN is associated with the trigeminal sensory pathway, however, the etiology of TN remains unclear. Implementing a graph-theory analysis using diffusion MRI we tested whether whole brain network structural connectivity hierarchies differentiate between TN patients and healthy controls. We found aberrant centrality measures of various brain regions in TN. Specifically, this whole-brain data-driven network analysis was able to depict two major regions of the trigeminal sensory circuit, the brainstem and thalamus, and highlight their dysfunction role in the whole brain network.

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