Abstract #3369

Probing Liver Microstructure in-vivo Using Diffusion-Relaxation Correlation Spectroscopic Imaging (DR-CSI)

Daeun Kim¹, Brian P Lee², Junzhou Chen^1,3, Kevin King¹, Justin P Haldar^4,5, Norah A Terrault², and Zhaoyang Fan^1,5,6

¹Department of Radiology, University of Southern California, Los Angeles, CA, United States, ²Department of Medicine, Division of Gastroenterology and Liver Diseases, University of Southern California, Los Angeles, CA, United States, ³Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ⁵Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ⁶Department of Radiation Oncology, University of Southern California, Los Angeles, CA, United States

Synopsis

Diffusion-relaxation correlation spectroscopic imaging (DR-CSI) is an advanced microstructure imaging approach that can resolve sub-voxel tissue compartments and quantify their fractions. In this work, we investigated the feasibility of DR-CSI with an optimized experiment design for in-vivo liver imaging. Our study showed that DR-CSI can measure multiple sub-voxel compartments in the liver and provide consistent component fraction maps in healthy livers. An initial test on a subject with chronic hepatitis B also demonstrated the potential of DR-CSI to identify and characterize pathological changes in liver parenchyma. Further studies on variable liver diseases are underway.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.