Abstract #3369
Probing Liver Microstructure in-vivo Using Diffusion-Relaxation Correlation Spectroscopic Imaging (DR-CSI)
Daeun Kim1, Brian P Lee2, Junzhou Chen1,3, Kevin King1, Justin P Haldar4,5, Norah A Terrault2, and Zhaoyang Fan1,5,6
1Department of Radiology, University of Southern California, Los Angeles, CA, United States, 2Department of Medicine, Division of Gastroenterology and Liver Diseases, University of Southern California, Los Angeles, CA, United States, 3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 4Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 5Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 6Department of Radiation Oncology, University of Southern California, Los Angeles, CA, United States
Synopsis
Diffusion-relaxation correlation spectroscopic imaging (DR-CSI) is an advanced microstructure imaging approach that can resolve sub-voxel tissue compartments and quantify their fractions. In this work, we investigated the feasibility of DR-CSI with an optimized experiment design for in-vivo liver imaging. Our study showed that DR-CSI can measure multiple sub-voxel compartments in the liver and provide consistent component fraction maps in healthy livers. An initial test on a subject with chronic hepatitis B also demonstrated the potential of DR-CSI to identify and characterize pathological changes in liver parenchyma. Further studies on variable liver diseases are underway.
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