Abstract #3368

Longitudinal assessment of nonalcoholic steatohepatitis with MRI and MRE – changes of imaging biomarkers and their relationships

Zheng Zhu¹, Jiahui Li¹, Usman Yaqoob², Alina M Allen², Terry Therneau³, Kevin J Glaser¹, Safa Hoodeshenas¹, Sudhakar K Venkatesh¹, Armando Manduca¹, Vijay H Shah², Richard L Ehman¹, and Meng Yin¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, ³Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States

Synopsis

We measured the longitudinal change of MRE-assessed liver stiffness (LS), loss modulus (LM) and MRI-assessed proton density fat fraction (PDFF) in a preclinical NASH model of 25 rats and 52 patients with NAFLD to assess disease severity, as well as the direction of progression/regression. Our pilot studies suggest that ΔLM and ΔPDFF are promising for monitoring treatment effects in a short-term period, while ΔLS is recommended for stratifying significant fibrosis that needs treatment in long-term follow-ups.

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