We measured the longitudinal change of MRE-assessed liver stiffness (LS), loss modulus (LM) and MRI-assessed proton density fat fraction (PDFF) in a preclinical NASH model of 25 rats and 52 patients with NAFLD to assess disease severity, as well as the direction of progression/regression. Our pilot studies suggest that ΔLM and ΔPDFF are promising for monitoring treatment effects in a short-term period, while ΔLS is recommended for stratifying significant fibrosis that needs treatment in long-term follow-ups.
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