Longitudinal assessment of nonalcoholic steatohepatitis with MRI and MRE – changes of imaging biomarkers and their relationships
Zheng Zhu1, Jiahui Li1, Usman Yaqoob2, Alina M Allen2, Terry Therneau3, Kevin J Glaser1, Safa Hoodeshenas1, Sudhakar K Venkatesh1, Armando Manduca1, Vijay H Shah2, Richard L Ehman1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States
We measured the longitudinal change of MRE-assessed liver stiffness (LS), loss modulus (LM) and MRI-assessed proton density fat fraction (PDFF) in a preclinical NASH model of 25 rats and 52 patients with NAFLD to assess disease severity, as well as the direction of progression/regression. Our pilot studies suggest that ΔLM and ΔPDFF are promising for monitoring treatment effects in a short-term period, while ΔLS is recommended for stratifying significant fibrosis that needs treatment in long-term follow-ups.
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