Abstract #3371

Diffusion and perfusion MRI for prediction of HCC response to neoadjuvant immunotherapy

Enamul Bhuiyan^1,2, Paul Kennedy^1,2, Octavia Bane^1,2, Muhammed Shareef², Stefanie Hectors³, Hung Kam Cheung ³, Elizabeth Miller³, M. Isabel Fiel⁴, Myron Schwartz⁵, Stephen Ward⁴, Thomas Marron⁶, Miriam Merad⁷, and Bachir Taouli^1,2

¹BioMedical Engineering and Imaging Institute (BMEII), Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Regeneron Pharmaceuticals Inc. Tarrytown, New York, NY, United States, ⁴Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁶The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁷Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Neoadjuvant immunotherapy has the potential to decrease the risk of hepatocellular carcinoma (HCC) recurrence post resection. The objectives of this study were to assess the value of pre-treatment MRI parameters for prediction of HCC immunophenotype and response in a cohort of patients undergoing neoadjuvant immunotherapy prior to liver resection. We hypothesize that diffusion and perfusion MRI can predict HCC response to neoadjuvant immunotherapy. It was observed that abundant of TILs decreases ADC in tumors. Moreover, uptake rate is higher in highly necrotic tumors.

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