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Abstract #3381

Comparison of Spiral and Cartesian Acquisitions for Rapid Hyperpolarized 129Xe Ventilation Mapping in Pediatric Cystic Fibrosis Lung Disease

Brandon Zanette1, Samal Munidasa1,2, Yonni Friedlander1,2, Felix Ratjen1,3, and Giles Santyr1,2
1Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada


A rapid 3D stack-of-spirals (3D-SoS) sequence was used for hyperpolarized 129Xe ventilation imaging in pediatric cystic fibrosis and healthy controls, allowing for 5x reduction in scan duration and breath-hold compared to a commonly used 2D gradient echo (2D-GRE) sequence. The ventilation defect percent (VDP) measured with 3D-SoS was not significantly different from VDP measured with 2D-GRE. Additionally, the transient drop in SpO2 associated with xenon breath-holds was reduced with the shorter breath-hold afforded by 3D-SoS. In future, the reduced acquisitions durations offered by 3D-SoS may allow for improved tolerability, or may be traded for improved resolutions.

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