A rapid 3D stack-of-spirals (3D-SoS) sequence was used for hyperpolarized 129Xe ventilation imaging in pediatric cystic fibrosis and healthy controls, allowing for 5x reduction in scan duration and breath-hold compared to a commonly used 2D gradient echo (2D-GRE) sequence. The ventilation defect percent (VDP) measured with 3D-SoS was not significantly different from VDP measured with 2D-GRE. Additionally, the transient drop in SpO2 associated with xenon breath-holds was reduced with the shorter breath-hold afforded by 3D-SoS. In future, the reduced acquisitions durations offered by 3D-SoS may allow for improved tolerability, or may be traded for improved resolutions.
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