We applied a deep learning (DL) model developed for 18F-FDG PET/CT of mantle cell lymphoma to esophageal cancers on 18F-FDG PET/CT and diffusion-weighted MRI. We compared the performance of the DL-based segmentation with the manual segmentation on PET and evaluated the quantitation on both PET and apparent diffusion coefficient (ADC). The model achieved promising results of detecting and segmenting esophageal cancers, and the DL-based imaging metrics were consistent with the reference standards.
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