Abstract #3385
Classifying healthy versus NAFLD mice from liver fatty acids’ 1H-MRS at 9.4 T using SVMs
Pedro Izquierdo Lehmann1,2, Aline Xavier2,3,4, Marcelo Andia2,4,5, and Carlos A Sing-Long1,2,4,6,7
1Institute for Mathematical and Computational Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, 3Instituto de Ciencias de la Ingeniería, Universidad de O’Higgins, Rancagua, Chile, 4Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 7Millennium Nucleus Center for the Discovery of Structure in Complex Data, Santiago, Chile
Synopsis
Nonalcoholic fatty liver disease (NAFLD) is a common liver disorder that is the first step in a cascade of liver damage. Hence, there is a clinical need for non-invasive, early identification of patients. We hypothesize that the intra-hepatocyte fatty acid composition provides information about NAFLD. To test this, the 1H-MRS spectra of fatty acids in the livers of healthy and NAFLD mice were measured at 9.4 T. Exploratory data analysis shows the spectra can be correctly classified with SVMs. Our results open an opportunity to develop a non-invasive tool for staging NAFLD patients without the need of liver biopsy.
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