MR-based Liver Iron Quantification using Gradient Echo: Co-Factors influencing the Calibration of R2* with Reference Liver Iron Content Values
Arthur Peter Wunderlich1,2, Holger Cario3, Stephan Kannengießer4, Lena Hering1, Michael Götz1,2, Meinrad Beer1, and Stefan Andreas Schmidt1
1Dept. for Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, 3Clinic of Pediatrics and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany
Purpose: To analyze the Liver-Iron-Content-(LIC)-R2*-calibration with respect to co-factors.
Methods: 116 patients were scanned with spin-echo (Ferriscan® protocol) and gradient-echo sequences. R2* was correlated to LIC reference values for all patients together and in subgroups divided by e.g. age, gender and underlying diseases. Linear correlations were analyzed with R2* only and including MR-PDFF as suspected co-factor.
Results: Deviating slopes of regression lines were found e.g. in patients after splenectomy vs. patients with spleen, influence of MR-PDFF amongst others in females below 17 years.
Conclusion: Co-factors like disease patterns should be considered in gradient echo based LIC quantification.
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