Purpose: To analyze the Liver-Iron-Content-(LIC)-R2*-calibration with respect to co-factors.
Methods: 116 patients were scanned with spin-echo (Ferriscan® protocol) and gradient-echo sequences. R2* was correlated to LIC reference values for all patients together and in subgroups divided by e.g. age, gender and underlying diseases. Linear correlations were analyzed with R2* only and including MR-PDFF as suspected co-factor.
Results: Deviating slopes of regression lines were found e.g. in patients after splenectomy vs. patients with spleen, influence of MR-PDFF amongst others in females below 17 years.
Conclusion: Co-factors like disease patterns should be considered in gradient echo based LIC quantification.
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