Abstract #3397

MRI quantitative assessment of muscular changes associated to a rehabilitation strategy in FSHD patients

Camille Noël^1,2, Constance Patricia Michel¹, Amira Trabelsi¹, Sébastien Vansteenkiste², Emmanuelle Salort-Campana³, Maëva Cotinat^2,4, Virginie De Bovis Milhe³, Laurent Bensoussan^2,4,5, Shahram Attarian³, and David Bendahan¹

¹Aix Marseille University, Center for magnetic resonance in biology and medecine, Marseille, France, Metropolitan, ²Physical and Rehabilitation Medecine Departement, APHM, Marseille, France, Metropolitan, ³Reference Centre for Neuromuscular Diseases and ALS, APHM, Marseille, France, Metropolitan, ⁴CNRS, INT UMR 7289, Aix Marseille University, Marseille, France, Metropolitan, ⁵UGECAM Institut Universitaire de Réadaptation de Valmante Sud, Marseille, France, Metropolitan

Synopsis

Facioscapulohumeral dystrophy is the third genetic myopathy. Given that no therapeutic strategy has proved to be successful, rehabilitation has been considered as an interesting alternative. The aim of this study was to quantitatively evaluate the effects of a personalized rehabilitation strategy using MRI by tracking fat fraction (FF) and contractile volume (CV) over time. The lower limb was scanned before and after a rehabilitation program. FF and CV remained stable over the training period. Clinical parameters evolved positively. FF and CV were correlated to isokinetic strength thereby indicating that both metrics could be considered as biomarkers of the pathology progression.

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