MRI quantitative assessment of muscular changes associated to a rehabilitation strategy in FSHD patients
Camille Noël1,2, Constance Patricia Michel1, Amira Trabelsi1, Sébastien Vansteenkiste2, Emmanuelle Salort-Campana3, Maëva Cotinat2,4, Virginie De Bovis Milhe3, Laurent Bensoussan2,4,5, Shahram Attarian3, and David Bendahan1
1Aix Marseille University, Center for magnetic resonance in biology and medecine, Marseille, France, Metropolitan, 2Physical and Rehabilitation Medecine Departement, APHM, Marseille, France, Metropolitan, 3Reference Centre for Neuromuscular Diseases and ALS, APHM, Marseille, France, Metropolitan, 4CNRS, INT UMR 7289, Aix Marseille University, Marseille, France, Metropolitan, 5UGECAM Institut Universitaire de Réadaptation de Valmante Sud, Marseille, France, Metropolitan
Facioscapulohumeral dystrophy is the third genetic myopathy. Given that no therapeutic strategy has proved to be successful, rehabilitation has been considered as an interesting alternative. The aim of this study was to quantitatively evaluate the effects of a personalized rehabilitation strategy using MRI by tracking fat fraction (FF) and contractile volume (CV) over time. The lower limb was scanned before and after a rehabilitation program. FF and CV remained stable over the training period. Clinical parameters evolved positively. FF and CV were correlated to isokinetic strength thereby indicating that both metrics could be considered as biomarkers of the pathology progression.
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