Abstract #3398

Validation of Muscle Fiber Architecture of the Human Tongue Revealed by Diffusion MRI with Histology Verification

Xiao Liang¹, Nahla M H Elsaid², Li Jiang¹, Steve Roys¹, Maureen Stone³, Jerry L Prince⁴, Adam C Puche⁵, Rao P Gullapalli¹, and Jiachen Zhuo¹

¹Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States, ³Department of Neural and Pain Sciences and Department of Orthodontics, University of Maryland School of Dentistry, Baltimore, MD, United States, ⁴Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁵Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Advanced dMRI techniques have been used to resolve the complex tongue muscle architecture. However, dMRI-derived tongue muscle architecture has not been validated with histology. In this study, we validated the dMRI-derived tongue muscle architecture with histology of a tongue specimen. dMRI was acquired for a post-mortem head and a healthy volunteer. dMRI-derived muscle fiber orientations, visualized as the tractogram, were compared against microscopic histology slices of the tongue specimen. Muscle fibers in the tractograms show good correspondence with those appearing in the histology images. The study demonstrates that dMRI can accurately reveal the complex muscle architecture of the human tongue.

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