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Abstract #3402

Bilateral characterization of fractional anisotropy within the anterior cruciate ligament: A step toward clinical use of DTI in the knee

Allen A Champagne1, Andrew McGuire2, Kaden Shearer1, Don Brien3, Paul A Martineau4, and Davide D Bardana2
1School of Medicine, Queen's University, Kingston, ON, Canada, 2Department of Orthopedic Surgery, Queen's University, Kingston, ON, Canada, 3Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada, 4Department of Orthopedic Surgery, McGill University, Montréal, QC, Canada


Diffusion tensor imaging (DTI) has emerged as biomarker to characterize the ligamentization process of the anterior cruciate ligament (ACL), following surgical reconstruction. One major limitation to this approach is the necessity for pre-injury baseline measurements to be used as a frame of reference, in order to inform clinical decision making with respect to recovery of the graft, and return-to-activity (RTA). Here, we explore the linear relationship for anisotropy between knees bilaterally, in healthy participants, to provide a methodological framework that allows for the clinical integration of DTI to monitor recovery of the tendon autograft, following surgical reconstruction, and inform RTA.

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