Cerebellar damage, by medulloblastoma and related surgery, induces global cerebral microstructural
Joseph Holtrop1, John R Glass1, Stuart S McAfee1, Silu Zhang1, Matthew A Scoggins1, Amar Gajjar2, Giles W Robinson2, Wilbur E Reddick1, and Asim K Bag1
1Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Department of Pediatrics, St. Jude Children's Research Hospital, Memphis, TN, United States
Survivors of medulloblastoma patients frequently have cognitive impairment, which is currently thought to be due to radiation and chemotherapy. In this work, we have showed that there is widespread changes in diffusion tensor parameters in cerebral white and gray matters, suggestive of brain microstructure damage, even before start of radiation and chemotherapy and not related to hydrocephalus.
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