Diffuse gliomas demonstrate significant spatial heterogeneity which is not captured on standard anatomical MRI or with existing diffusion MRI (dMRI) methods. This is because current dMRI approaches provide voxel-averaged information about tissue composition and are based on a priori assumptions about underlying tissue microstructure, thus providing a simplified model of tissue properties. Here, we apply an unbiased, model-agnostic dMRI method (model-free diffusion tensor distribution (FDTD) and K-means clustering) to seven subjects with diffuse gliomas. We confirm the presence of intratumoral heterogeneity and find distinct differences in diffusion properties between gliomas of different histologic grades and pre- and post-treatment.
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