Meeting Banner
Abstract #3407

Identifying Metabolic Differentiators of Small Cell Neuroendocrine versus Adenocarcinoma subtypes of Castration-Resistant Prostate Cancer

Deepti Upadhyay1, Jinny Sun1, Shubhangi Agarwal1, Robert Bok1, Romelyn DeLos Santos1, Donna Peehl1, John Kurhanewicz1, and Renuka Sriram1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States


NMR-based stable isotope resolved metabolomics was used to characterize small cell neuroendocrine (SCNC) and adenocarcinoma (aCRPC) subtypes of castration-resistant prostate cancer patient-derived xenografts (PDXs). Targeted metabolomics indicated distinct upregulation of metabolic pathways in SCNC relative to aCRPC PDXs. Specifically, [U-13C]glucose and [U-13C]glutamine labeling demonstrated that SCNC PDXs had increased glycolytic rate, alanine aminotransferase and tricarboxylic acid cycle activity, including anaplerotic sources. Further, the metabolic differences observed among the aCRPC and SCNC PDXs exhibited a continuous range as predicted by clinical genomic data of these subtypes of CRPC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here