Abstract #3410

Characterizing Restricted Diffusion in Pre-/Post- treatment Gliomas Using Time-dependent Diffusion MRI at Ultra-high-gradient Human 3.0T

Ante Zhu¹, Robert Y. Shih^2,3, James Kevin DeMarco^2,3, Herman Douglas Morris^2,3, Radhika Madhavan¹, Gail Kohls^2,3, Tim Sprenger⁴, Maureen Hood^2,3, Luca Marinelli¹, Jason A. Gregory^2,3, Brett J. Theeler^2,3, Vincent B. Ho^2,3, and Thomas K.F. Foo¹

¹Biology and Applied Physics, GE Research, Niskayuna, NY, United States, ²Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ³Walter Reed National Military Medical Center, Bethesda, MD, United States, ⁴GE Healthcare, Stockholm, Sweden

Synopsis

Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC(f) and kurtosis MK(f) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC(f) and MK(f) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC(f) and MK(f) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence.

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