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Abstract #3410

Characterizing Restricted Diffusion in Pre-/Post- treatment Gliomas Using Time-dependent Diffusion MRI at Ultra-high-gradient Human 3.0T

Ante Zhu1, Robert Y. Shih2,3, James Kevin DeMarco2,3, Herman Douglas Morris2,3, Radhika Madhavan1, Gail Kohls2,3, Tim Sprenger4, Maureen Hood2,3, Luca Marinelli1, Jason A. Gregory2,3, Brett J. Theeler2,3, Vincent B. Ho2,3, and Thomas K.F. Foo1
1Biology and Applied Physics, GE Research, Niskayuna, NY, United States, 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 3Walter Reed National Military Medical Center, Bethesda, MD, United States, 4GE Healthcare, Stockholm, Sweden


Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC(f) and kurtosis MK(f) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC(f) and MK(f) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC(f) and MK(f) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence.

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