Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC(f) and kurtosis MK(f) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC(f) and MK(f) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC(f) and MK(f) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence.