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Abstract #3423

In Vivo Oxygen Imaging of Implanted Islet Encapsulation Devices

Mrignayani Kotecha1, Navin Viswakarma1, Eliyas Siddiqui1, Sonny Patel1, and Boris Epel2
1O2M Technologies, LLC, Chicago, IL, United States, 2Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, United States


The lack of oxygen supply to the highly metabolic pancreatic islet cells is one of the major factors contributing to the failure of islet transplantation devices designed to cure type I diabetes (T1D). Several approaches to improve oxygenation in these devices have been developed. However, the lack of available technologies to provide reliable pO2 assessment in and around devices hinders the progress severely. We performed in vivo oxygen imaging of cell loaded encapsulation devices using pulse electron paramagnetic resonance oxygen imaging (EPROI) technique. For the first time, whole-body EPROI is used to monitor pO2 of implanted devices in this work.

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