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Abstract #3427

Deuterium (2H) MR Spectroscopy Distinguishes Tumor (Glioblastoma) from Radiation Necrosis in Mouse Brain

Kyu-Ho Song1, John A. Engelbach1, James D. Quirk1, Keith M. Rich2,3, Joseph J.H. Ackerman1,4,5,6, and Joel R. Garbow1,6
1Department of Radiology, Washington University, St. Louis, MO, United States, 2Department of Neurosurgery, Washington University, St. Louis, MO, United States, 3Department of Radiation Oncology, Washington University, St. Louis, MO, United States, 4Department of Chemistry, Washington University, St. Louis, MO, United States, 5Department of Internal Medicine, Washington University, St. Louis, MO, United States, 6Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, United States

Synopsis

Employing mouse models of radiation necrosis (one that displays the histologic hallmarks of the clinical condition) and glioblastoma (GL261), deuterium (2H) MR spectroscopy, in concert with infusion of 2H-labelled glucose, was employed to ascertain whether the 2H MRS signatures could differentiate the two lesions, an unmet clinical need. The 2H MR metabolic profiles of the two lesions were markedly different. In the tumor, the Warburg effect (aerobic glycolysis, fermentation) converted glucose nearly exclusively to lactate. In radiation necrosis, oxidative phosphorylation (respiration) dominated, with glucose converting to TCA cycle intermediates glutamate and glutamine. Thus, 2H MR distinguishes glioblastoma vs. radiation necrosis.

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