Abstract #3433
Optimization of a highly sensitivity 19F MRI probe for NK cell immunotherapy tracking
Gary Martinez1, Dmitry Nevozhay2, Juan C Bournat3, Donghang Cheng3, Ajay Sharma3, Tyler King4, Emily Que5, Vidya Gopalakrishnan6, Konstantin Sokolov1, and James A Bankson1
1Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Dmitry Nevozhay, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4Chemistry, The University of Texas at Austin, Austin, TX, United States, 5The University of Texas at Austin, Austin, TX, United States, 6The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Synopsis
NK cell immunotherapy has great potential as a safe and effective anticancer therapy yet there are significant challenges for immunotherapy in brain tumors. We have developed a 19F probe with enhanced sensitivity for the purposes of 19F labeling of NK cells to monitor NK cell biodistribution and immunotherapy. In this paper, we report on the relaxometric characteristics of the probe, acquisition optimization, and initial ex vivo imaging tests in murine models. The agent displayed improved sensitivity relative to Celsense and was clearly visible in the cerebral cortex in approximately equivalent amounts that will be used for cell tracking experiments.
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