Abstract #3433

Optimization of a highly sensitivity 19F MRI probe for NK cell immunotherapy tracking

Gary Martinez¹, Dmitry Nevozhay², Juan C Bournat³, Donghang Cheng³, Ajay Sharma³, Tyler King⁴, Emily Que⁵, Vidya Gopalakrishnan⁶, Konstantin Sokolov¹, and James A Bankson¹

¹Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²Dmitry Nevozhay, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ³Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴Chemistry, The University of Texas at Austin, Austin, TX, United States, ⁵The University of Texas at Austin, Austin, TX, United States, ⁶The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Synopsis

NK cell immunotherapy has great potential as a safe and effective anticancer therapy yet there are significant challenges for immunotherapy in brain tumors. We have developed a 19F probe with enhanced sensitivity for the purposes of 19F labeling of NK cells to monitor NK cell biodistribution and immunotherapy. In this paper, we report on the relaxometric characteristics of the probe, acquisition optimization, and initial ex vivo imaging tests in murine models. The agent displayed improved sensitivity relative to Celsense and was clearly visible in the cerebral cortex in approximately equivalent amounts that will be used for cell tracking experiments.

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