Brain Connectomics in a Mouse Model of Early and Late Stage Pruritus
Talaignair N Venkatraman1, Ouyang Chen2, Allen W Song3, Ru-Rong Ji2, and Chris D Lascola3
1Radiology, Duke University Medical Center, Durham, NC, United States, 2Anesthesiology, Duke University Medical Center, Durham, NC, United States, 3BIAC and Radiology, Duke University Medical Center, Durham, NC, United States
We performed high-resolution ex-vivo DTI in mice with cutaneous T-Cell lymphoma (CTCL) in a mouse model of pruritus. Our results show significant network changes within and between specific brain regions, namely thalamus and hippocampus, by the later stage of disease. At the chronic stage (55 days), micro-structural changes and enhanced connectivity are established between the hippocampus and thalamus.
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