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Abstract #3437

Investigating the origin of the BOLD initial dip with biophysical simulations based on realistic microvascular networks: flow or metabolism?

Joerg Peter Pfannmoeller1, Grant Adison Hartung1, Avery Berman1, and Jonathan Rizzo Polimeni1
1Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States


We used simulations to achieve insights about the nature of the initial dip and found that it is indeed possible that retrograde propagation causes a local decoupling between hemodynamics and neural activity localized to the upper layers of the cortex. The simulations allowed to assess the contributions of the different simultaneously occurring contributions and point towards a high specificity of the initial dip to the capillaries or the veins. A methodological difficulty was posed by the limited availability of arterial dilation data. Therefore, we derived dilation traces from the measurements and determine a range of possible propagation velocities.

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