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Abstract #3439

Investigating time-restricted feeding and metabolic sexual dimorphism in Nile grass rats by time-domain NMR lipid profiling

Hayden Johnson1, Thomas Yates1, Chidambaram Ramanathan2, Melissa Puppa2, Marie van der Merwe2, and Aaryani Tipirneni-Sajja1
1Biomedical Engineering, University of Memphis, Memphis, TN, United States, 2College of Health Sciences, University of Memphis, Memphis, TN, United States


NMR-based metabolomics is a powerful technique for elucidating the metabolic effects of diet through the identification and quantification of molecules present in tissues. This study utilizes time-domain processing of NMR data for robust, reproducible resonance characterization in the profiling of lipid species in heart and liver tissues of male and female animals subject to high fat diets with and without time-restriction. Results show triglyceride and fatty acid accumulation was associated with eating a high fat diet, but these effects were attenuated by time-restricted feeding. Hepatic lipids expressed a sexually dimorphic response, with higher concentrations of many lipids in female subjects.

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