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Abstract #3507

Once upon a chiasm: Reconstruction of mouse optic pathways with ODF-Fingerprinting

Patryk Filipiak1, Thajunnisa A. Sajitha2, Timothy Shepherd1, Ying-Chia Lin1, Dimitris G. Placantonakis3, Kevin C. Chan2, Fernando E. Boada1, and Steven H. Baete1
1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Langone Health, New York, NY, United States, 2NeuroImaging and Visual Science Laboratory, Departments of Ophthalmology and Radiology, NYU Langone Health, New York, NY, United States, 3Department of Neurosurgery, Perlmutter Cancer Center, Neuroscience Institute, Kimmel Center for Stem Cell Biology, NYU Langone Health, New York, NY, United States

Synopsis

We reconstruct mouse optic pathways with ODF-Fingerprinting in a challenging crossing area of the optic chiasm. Our method replaces the commonly used peak finding approach with pattern matching when reconstructing white matter fiber directions from orientation distribution functions. As reference, we perform analogous reconstructions using Radial Diffusion Spectrum Imaging and Generalized Q-space Imaging. To obtain ground truth information, we inject intravitreally a 0.1M solution of manganese chloride into four C57BL/6N mice. The optic pathways reconstructed with deterministic tractography based on directional information calculated with our approach reach higher agreement with the ground truth than the other two methods.

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Keywords