This study presents a volumetric extension of the previously proposed patch-based algorithm for enhancing spatial resolution of 13C MRI. Feasibility of integrating structural and perfusion images as guidance for the patch-based reconstruction is also demonstrated with a digital phantom. The performance of the method was further tested for a hyperpolarized 13C lactate brain image using hybrid probability maps, created from T1-weighted 1H MRI and perfusion images.
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