Diffusion-weighted MRSI (DW-MRSI) is a unique quantitative molecular imaging modality that can potentially provide exclusive cell-type and compartment-specific microstructural information in vivo. However, DW-MRSI studies have been largely limited to single voxels or very low resolutions in basic science and clinical applications due to several fundamental technical challenges. Here, we further enhanced the performance and robustness of the recently proposed subspace imaging method by synergizing improved acquisition and data processing strategies. Higher b-value DE and 3D metabolite mean diffusivity mapping more immune to physiological motions at a 6.9x6.9x8 mm3 nominal resolution were achieved in less than 20-mins.
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