Abstract #3525
A Dissolved-Phase 129Xe Phantom for Quantitative Gas-Exchange MRI
Brice Albert1, Joseph W Plummer2, Matthew M Willmering1, Diana M Lindquist3,4,5, Laura L Walkup1,2,6,7, and Zackary I Cleveland1,2,6,7
1Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States, 5Department of Radiology, University of Cincinnati, Cincinnati, OH, United States, 6Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 7Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
Synopsis
Many single-site studies, and increasingly multi-site clinical trials, employ hyperpolarized 129Xe MRI to assess lung structure and function. The lack of reliable imaging 129Xe standards hampers image quantification and rigorous comparisons across research sites. This is particularly true for 129Xe imaging of pulmonary gas-exchange, which must detect the large gaseous resonance and the two, 50-fold-smaller 129Xe dissolved resonances, corresponding to 129Xe dissolved in red bloods cells and adjacent plasma/parenchymal barrier tissues. This work demonstrates the feasibility of constructing practical, thermally-polarized, dissolved-phase 129Xe phantoms that mimic in-vivo resonances and will enable multi-site studies of gas-exchange imaging to be harmonized.
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