Hyperpolarized 129Xe MRI can non-invasively measure regional ventilation by mapping the spin-density of inhaled gas, thus providing insights into regional disease pathophysiology. However, the quantitative accuracy of 129Xe ventilation imaging is reduced by B1-inhomogeneity causing spatial variations in both coil sensitivity and nonequilibrium magnetization decay. These can cause lung function impairment to be either over or underestimated. We demonstrate these artifacts can be mitigated by generating flip angle maps from paired 2D-spiral images acquired in the same held breath. This yields quantitatively comparable results to those obtained with a conventional, 2D gradient recalled echo sequence in substantially reduced acquisition times.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords