User-Friendly Application for Consistent Multi-Vendor Hyperpolarized 129Xe MRI Analysis
Abdullah S. Bdaiwi1,2, Joseph W. Plummer1,2, Matthew M. Willmering1, David J. Roach1, Jason C. Woods1,3,4, Laura L. Walkup1,2,3,4, and Zackary L. Cleveland1,2,3,4
1Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 4Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States
Advances hyperpolarized 129Xe production, data acquisition and image analysis have allowed 129Xe MRI to emerge as a leading pulmonary imaging modality. As the number of sites capable of 129Xe MRI and quantitative image-derived metrics grow, the need for an intuitive, organized analysis tool increases. Here, we provide a user-friendly application, designed as MATLAB language-based interface, to analyze HP 129Xe data. This open-source, research tool enables standardized analysis of hyperpolarized 129Xe calibration, ventilation, diffusion, and gas-exchange data. Furthermore, the modular design allows developers to easily implement additional functions and analysis procedures, providing a framework for growth and sharing of analysis techniques.
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