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Abstract #3530

Feasibility of the Ventilatory ADC Approach Using Hyperpolarized 129Xe Pulmonary MRI

Elnaz Parniyany1, Elise Woodward 1, Tingting Wu1, Matthew S Fox1,2, and Alexei Ouriadov1,2,3
1Physics and Astronomy, The University of Western Ontario, London, ON, Canada, 2Lawson Health Research Institute, London, ON, Canada, 3School of Biomedical Engineering, Faculty of Engineering, The University of Western Ontario, London, ON, Canada

Synopsis

Hyperpolarized 129Xe lung MRI is an efficient technique used to investigate and assess pulmonary diseases. However, the longitudinal observation of the emphysema progression using hyperpolarized gas MRI-based ADC can be problematic, as the disease-progression can lead to increasing unventilated-lung areas, which likely excludes the largest ADC estimates. One solution to this problem is to combine static-ventilation and ADC measurements following the idea of 3He MRI ventilatory ADC (vADC). We have demonstrated this method adapted for 129Xe MRI to help overcome the above-mentioned shortcomings and provide an accurate assessment of the emphysema progression.

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