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Abstract #3531

Inductively Coupled Floating Coil for Hyperpolarized 13C Imaging of Mouse Brain

Atsushi M. Takahashi1, David Guarin2,3, Erin E. Hardy3, Julie Miller4, Hiroaki Wakimoto5, Daniel P. Cahill5, and Yi-Fen Yen3
1Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Polarize ApS, Frederiksberg, Denmark, 3Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 5Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States


We report an inductively coupled floating coil designed for hyperpolarized 13C MR spectroscopic imaging of mouse brain, with emphases on the simplicity of the circuit design, the ease of use, whole-brain coverage, and high SNR obtained. The floating coil is designed to “crown” the mouse head for a snug fit to achieve full coverage of the brain with good sensitivity. Here, we demonstrated the coil’s performance in normal mouse and glioblastoma multiforme mouse model at 4.7 T using a next-generation hyperpolarizer. High signal to noise ratio exceeding 70:1 was obtained in the brain with good spatial resolution (1.53mm x 1.53mm).

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