Abstract #3531

Inductively Coupled Floating Coil for Hyperpolarized 13C Imaging of Mouse Brain

Atsushi M. Takahashi¹, David Guarin^2,3, Erin E. Hardy³, Julie Miller⁴, Hiroaki Wakimoto⁵, Daniel P. Cahill⁵, and Yi-Fen Yen³

¹Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States, ²Polarize ApS, Frederiksberg, Denmark, ³Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ⁵Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States

Synopsis

We report an inductively coupled floating coil designed for hyperpolarized ¹³C MR spectroscopic imaging of mouse brain, with emphases on the simplicity of the circuit design, the ease of use, whole-brain coverage, and high SNR obtained. The floating coil is designed to “crown” the mouse head for a snug fit to achieve full coverage of the brain with good sensitivity. Here, we demonstrated the coil’s performance in normal mouse and glioblastoma multiforme mouse model at 4.7 T using a next-generation hyperpolarizer. High signal to noise ratio exceeding 70:1 was obtained in the brain with good spatial resolution (1.53mm x 1.53mm).

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