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Abstract #3532

Feasibility of Simultaneous Measurements of GABA, Glx and GSH in the Thalamus Using HERMES

Xiao Liang1, Muhammad G Saleh1, Steve Roys1, Rao P Gullapalli1, and Jiachen Zhuo1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States


It is desirable to measure GABA, glutamate, and GSH in the thalamus for understanding pathological and pharmacokinetic changes. In this study, we study the feasibility of simultaneous measurements of these metabolites in the thalamus using HERMES. HERMES data were acquired on 20 healthy adult volunteers with and without saturation bands. HERMES data were processed in Gannet with and without spectral alignment. The results demonstrated the feasibility of using HERMES for simultaneous measurements of GABA, Glx and GSH in the thalamus. HERMES combined with saturation bands and retrospective spectral alignment yields high SNR spectra and reproducible measurements in the thalamus.

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