Magnetic resonance spectroscopy (MRS) allows non-invasive pH measurements via the chemical shift difference between a pH-dependent resonance and a reference. We studied the pH dependence of taurine chemical shifts in 1H MRS for a wide range of pH and temperature. At 37°C and in the physiological range (pH ~7.3), the chemical shifts show a bijective dependence on pH. This approach was evaluated by measurements on taurine phantoms using solutions with different pH and temperatures, demonstrating the possibility of absolute pH determination via the chemical shift of taurine.
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