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Abstract #3538

pH-dependence of taurineĀ 1H NMR chemical shifts: A potential method for pH determination and imaging

Felizitas Charlotte Wermter1, Wolfgang Dreher1, and Christian Bock2
1in-vivo MR, University Bremen, Bremen, Germany, 2Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany


Magnetic resonance spectroscopy (MRS) allows non-invasive pH measurements via the chemical shift difference between a pH-dependent resonance and a reference. We studied the pH dependence of taurine chemical shifts in 1H MRS for a wide range of pH and temperature. At 37°C and in the physiological range (pH ~7.3), the chemical shifts show a bijective dependence on pH. This approach was evaluated by measurements on taurine phantoms using solutions with different pH and temperatures, demonstrating the possibility of absolute pH determination via the chemical shift of taurine.

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