Abstract #3537
Is tissue composition driving regional variation in neurometabolite levels?
Julie M Joyce1,2,3,4, Marilena DeMayo1,2,3,5,6, Chantel T Debert2,3,4,7, and Ashley D Harris1,2,3,4
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 4Integrated Concussion Research Program, University of Calgary, Calgary, AB, Canada, 5Department of Psychiatry, University of Calgary, Calgary, AB, Canada, 6Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada, 7Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Synopsis
Metabolite concentrations vary across brain regions. What remains unclear is the degree to which this variation is due to inherent regional differences or if it is driven by the composition of the underlying tissue. Using magnetic resonance spectroscopy, we show that apparent ‘regional differences’ in metabolite concentrations are driven by tissue composition for glutamate and glutathione. Furthermore, we provide evidence to suggest a need for a tissue correction for glutamate, glutathione and N-acetyl-aspartate that appropriately addresses differences in voxel gray matter and white matter content.
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