Metabolite concentrations vary across brain regions. What remains unclear is the degree to which this variation is due to inherent regional differences or if it is driven by the composition of the underlying tissue. Using magnetic resonance spectroscopy, we show that apparent ‘regional differences’ in metabolite concentrations are driven by tissue composition for glutamate and glutathione. Furthermore, we provide evidence to suggest a need for a tissue correction for glutamate, glutathione and N-acetyl-aspartate that appropriately addresses differences in voxel gray matter and white matter content.
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