Glutamate is the major excitatory neurotransmitter in the brain and malfunction of glutamatergic metabolism is associated with various neurological disorders. Respective metabolic rates can be determined via direct 13C or indirect 1H-[13C] MRS after intake of 13C labelled tracers. In this work, labeling effects after oral intake of [13C-1]glucose are observed in human brain using a 1H-FID-MRSI sequence at 9.4T. Spectral time series of GM and WM voxels as well as metabolite maps show regionally distinct and tissue type specific labelling induced changes of Glu and Gln spectral pattern that allow for the determination of 13C label uptake rates.
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