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Abstract #3540

Glutamate Metabolism Mapping after Oral Administration of 1-13C-Glc using 1H MRSI in the human brain at 9.4 T

Theresia Ziegs1, Loreen Ruhm1, Andrew Wright1, and Anke Henning1,2
1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States


Glutamate is the major excitatory neurotransmitter in the brain and malfunction of glutamatergic metabolism is associated with various neurological disorders. Respective metabolic rates can be determined via direct 13C or indirect 1H-[13C] MRS after intake of 13C labelled tracers. In this work, labeling effects after oral intake of [13C-1]glucose are observed in human brain using a 1H-FID-MRSI sequence at 9.4T. Spectral time series of GM and WM voxels as well as metabolite maps show regionally distinct and tissue type specific labelling induced changes of Glu and Gln spectral pattern that allow for the determination of 13C label uptake rates.

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