Accurate thermometry using hyperpolarized 129Xe free induction decay and spin-echo chemical shift imaging in rats
Agilo L Kern1,2, Marcel Gutberlet1,2, Regina Rumpel3, Inga Brüsch3, Jens M Hohlfeld2,4,5, Frank Wacker1,2, and Bennet Hensen1
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany, 4Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 5Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
Thermometry using the proton resonance frequency (PRF) is challenging in inhomogeneous, fatty tissues and moving organs. Purpose of this study was to develop and test a combined free induction decay (FID)/spin-echo chemical shift imaging sequence for accurate hyperpolarized 129Xe MR thermometry in rats exposed to hypothermia. Significant changes of 129Xe lipid chemical shift and good agreement with core body temperature are observed. Bland–Altman analysis shows narrower limits of agreement and reduced mean difference for spin-echo acquisitions, suggesting improved precision and accuracy in fatty tissues. The method may be valuable as reference standard for development of more accurate 1H MR thermometry.
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