A rapid chemical shift saturation recovery (CSSR) pulse sequence is developed for reconstructing CSSR uptake curves in different cardiac phases by employing retrospective gating. The sequence is tested in a study with 6 healthy volunteers and compared to conventional CSSR. A significant difference in septal wall thickness between trough and crest of the pulse wave in lung tissue is found. Results from rapid and conventional CSSR are strongly correlated and show good absolute agreement. The proposed rapid CSSR pulse sequence may provide valuable new insights into normal lung function, improve precision of CSSR results and may have clinical applications.
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