Changes in lung microstructure during the cardiac cycle assessed by rapid hyperpolarized 129Xe chemical shift saturation recovery
Agilo L Kern1,2, Marcel Gutberlet1,2, Jens M Hohlfeld2,3,4, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 4Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
A rapid chemical shift saturation recovery (CSSR) pulse sequence is developed for reconstructing CSSR uptake curves in different cardiac phases by employing retrospective gating. The sequence is tested in a study with 6 healthy volunteers and compared to conventional CSSR. A significant difference in septal wall thickness between trough and crest of the pulse wave in lung tissue is found. Results from rapid and conventional CSSR are strongly correlated and show good absolute agreement. The proposed rapid CSSR pulse sequence may provide valuable new insights into normal lung function, improve precision of CSSR results and may have clinical applications.
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