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Abstract #3543

Quantitative Metabolite Mapping of 12 Metabolites in the Human Brain

Andrew Martin Wright1,2 and Anke Henning1,3
1MRZ, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tübingen, Tübingen, Germany, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States


Very short TR (TR < 300) MRSI is a popular method that enables fast acquisition of spectroscopic imaging data; however, raw metabolite signals following short TR acquisitions are influenced by strong T1-weighting. In order to gather more accurate images and to be able to relate MRSI results to SVS studies, it is valuable to correct for T1-weighting and to quantify MRSI images. This study presents results that utilize a voxel-specific, T1-correction method which is an advancement from more traditional methods that utilized average T1-corrections for metabolites. Fully sampled, single-slice 1H MRSI metabolite maps are presented for 12 metabolites.

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