Abstract #3544

Simultaneous Mapping of Water Diffusion Coefficients and Metabolite Distributions of the Brain Using MRSI without Water Suppression

Rong Guo^1,2, Yudu Li^1,2, Yibo Zhao^1,2, Tianyao Wang³, Yao Li⁴, Brad Sutton^1,2,5, and Zhi-Pei Liang^1,2

¹Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Radiology Department, Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ⁴School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁵Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

The feasibility of high-resolution metabolic imaging using water-unsuppressed MRSI has been recently demonstrated in clinical settings using SPICE. This work utilizes the unsuppressed water spectroscopic signals for distortion-free mapping of water diffusion coefficients, thus adding a new feature to SPICE for multi-modal brain mapping. Experimental results demonstrated that simultaneous distortion-free diffusion imaging at 1.0×1.0×2.0 mm³ resolution and metabolic imaging at 2.0×3.0×3.0 mm³ nominal resolution were successfully obtained in a total 8-min scan.

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