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Abstract #3545

Axon radius mappingĀ using multi-TE diffusion MRI from clinical scanners

Lipeng Ning1 and Yogesh Rathi1
1Harvard Medical School, BWH, Boston, MA, United States


Diffusion MRI is sensitive to heterogeneity tissue microstructure. Recent methods for axon diameter estimation rely on diffusion MRI data acquired using advanced scanners with b-values higher than 6000 s/mm2 so that signals from extra-axonal components vanish because of the underlying relative high diffusivity. In this work, we introduce a method for axon diameter estimation that uses diffusion MRI with two TEs and relative lower b-values acquired using clinical scanners. Our method separates signals from intra- and extra-axonal components by exploiting the b-value-dependent relaxation coefficients. The performance of the proposed method is demonstrated using in vivo data acquired from a clinical scanner.

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