Time-dependent diffusivity is sensitive to microstructural geometry and has previously been described by a power-law scaling. However, the limits of validity of this relationship across different ranges of diffusion time are unclear. We therefore acquired brain images of nonhuman primates in vivo with diffusion times from 1.9 to 40 ms to assess how well a power-law fits diffusivity in this range. We assess fitting in the time and frequency domains, whether pulsed (PGSE) and oscillating (OGSE) gradient spin echo can be combined for better results, and the sensitivity of diffusivity estimates to varying power-law exponents.
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