Diffusion time dependence in the non-human primate brain
Sean P Devan1,2, Xiaoyu Jiang1,3, Kurt G Schilling1,3,4, Feng Wang1,3, Li Min Chen1,3, John C Gore1,3,4,5, and Junzhong Xu1,3,4,5
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 5Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States
Time-dependent diffusivity is sensitive to microstructural geometry and has previously been described by a power-law scaling. However, the limits of validity of this relationship across different ranges of diffusion time are unclear. We therefore acquired brain images of nonhuman primates in vivo with diffusion times from 1.9 to 40 ms to assess how well a power-law fits diffusivity in this range. We assess fitting in the time and frequency domains, whether pulsed (PGSE) and oscillating (OGSE) gradient spin echo can be combined for better results, and the sensitivity of diffusivity estimates to varying power-law exponents.
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