Abstract #3556

Repeatability of Susceptibility Separation in Brain

Javad Hamidi Esfahani¹, Nashwan Naji¹, Peter Seres¹, Christian Beaulieu¹, and Alan H Wilman¹

¹Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

Synopsis

Susceptibility separation enables a voxel-wise decomposition into paramagnetic and diamagnetic components. The repeatability of the method is examined in four structures of deep gray matter and three of white matter using scan rescan data of 22 subjects. The paramagnetic susceptibility separation is shown to be more robust than the diamagnetic and total susceptibility is shown to be similar to conventional QSM. Thus, susceptibility separation can provide both qualitative depiction of diamagnetic and paramagnetic susceptibility components and repeatable measures of paramagnetic components at least in deep grey matter.

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