Abstract #3557

Quantitative Susceptibility Mapping of the Ex Vivo Human Brainstem with Luxol Fast Blue Staining Correlation

Priya S Balasubramanian^1,2, Lingfei Guo^2,3, Weiyuan Huang^2,4, Ilhami Kovanlikaya², Alisa Ramineni⁵, Nector Garcia⁵, Benjamin Liechty⁵, Jonathan Dyke², Henning Voss², Eric Aronowitz², Pascal Spincemaille², David Pisapia⁵, and Yi Wang²

¹Electrical and Computer Engineering, CORNELL UNIVERSITY, New York City, NY, United States, ²Department of Radiology, Weill Cornell Medicine, New York City, NY, United States, ³Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, Jinan, Shandong, China, ⁴Department of Radiology, Hainan General Hospital, Hainan Hospital Affiliated to Hainan Medical College, Hainan, China, ⁵Department of Pathology and Laboratory Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York City, NY, United States

Synopsis

This study utilized sub-millimeter 3T gradient echo MRI of the brainstem ex vivo to obtain a magnetic susceptibility map (QSM). ROIs of both deep brain nuclei and myelinated fiber tracts were chosen and quantified from QSM obtained from MRI field. The ex vivo specimens were then stained with Luxol Fast Blue and the resultant absorbance of the ROIs were compared to QSM. A strong linear correlation was observed (R² = 0.897, p = 0.0041).

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