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Abstract #3560

High-SNR J-Resolved MRSI by Jointly Learning Nonlinear Representation and Projection

Yahang Li1,2, Zepeng Wang1,2, and Fan Lam1,2,3
1Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, Urbana, IL, United States, 3Cancer Center at Illinois, Urbana, IL, United States


J-resolved 1H-MRSI offers several unique advantages but suffers from long acquisition time and lmited SNR, especially for longer TEs. Leveraging the recent progress on constrained MRSI reconstruction using learned nonlinear low-dimensional representations, we propose here a new method for SNR-enhancing reconstruction from rapidly generated, noisy J-resolved data, that can computationally efficiently enforce an accurate nonlinear low-dimensional representation of high-dimensional J-resolved spectroscopic signals through a learned network-based project as well as complementary spatial constraints. The proposed method has been shown to improve the SNR significantly for in vivo J-resolved 1H-MRSI of the brain.

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