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Abstract #3561

Imaging Gas Exchange Using Hyperpolarized 129Xe as a Better Predictor of Endobronchial Valve Outcome

Hooman Hamedani1, Faraz Amzajerdian1, Stephen Kadlecek1, Ryan Baron1, Kai Ruppert1, Ian Duncan1, Mostafa Ismail1, Yi Xin1, Tahmina Achekzai1, Luis Loza1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States


Bronchoscopic lung volume reduction (LVR) using endobronchial valves has proven effective at improving lung function and quality of life in certain severely emphysematous patients. Successful lung volume reduction of the target lobe shifts ventilation and perfusion to the healthier ipsilateral lobe and improves breathing mechanics. Functional imaging with spatially-resolved metrics using inhaled hyperpolarized 129Xe (HXe) may provide a deeper understanding of the physiology underlying clinical benefit.

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