Bronchoscopic lung volume reduction (LVR) using endobronchial valves has proven effective at improving lung function and quality of life in certain severely emphysematous patients. Successful lung volume reduction of the target lobe shifts ventilation and perfusion to the healthier ipsilateral lobe and improves breathing mechanics. Functional imaging with spatially-resolved metrics using inhaled hyperpolarized 129Xe (HXe) may provide a deeper understanding of the physiology underlying clinical benefit.
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