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Abstract #3563

A Metabolite Specific 3D Stack-of-Spiral bSSFP Sequence for Improved 13C-Bicarbonate Imaging in Hyperpolarized [1-13C]Pyruvate MRI

Xiaoxi Liu1, Shuyu Tang2, Robert Bok1, Hsin-Yu Chen1, Changhua Mu1, Romelyn Delos Santos1, Avantika Sinha1, Zhen J. Wang1, and Peder E.Z. Larson1
1University of California San Francisco, San Francisco, CA, United States, 2HeartVista, Los Altos, CA, United States


MRI of hyperpolarized 13C-labeled compounds is an emerging tool to non-invasively detect metabolic processes, and hyperpolarized [1-13C]pyruvate has been used in clinics for assessing cancer and cardiac metabolism. However, due to nonrenewable and progressively depleted magnetization, hyperpolarized 13C has a limitation to achieve both high spatial resolution and temporal resolution with high SNR. This study proposes a novel bicarbonate-specific 3D bSSFP sequence with stack-of-spiral readout to improve the SNR of dynamic bicarbonate imaging in hyperpolarized [1-13C]pyruvate studies. Compared to a metabolite-specific GRE sequence, the proposed MS-3DbSSFP sequence showed a 3X SNR improvement for bicarbonate imaging in rat heart and kidneys.

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