Meeting Banner
Abstract #3564

Hyperpolarized [1-13C]Pyruvate MRI Using a Metabolite-Specific Rotated Echo-Planar Imaging Sequence with Half Scan

Xiaoxi Liu1, Di Cui1, Shuyu Tang2, Robert Bok1, Changhua Mu1, Hsin-Yu Chen1, Romelyn Delos Santos1, Avantika Sinha1, Jeremy Gordon1, and Peder E.Z. Larson1
1University of California San Francisco, San Francisco, CA, United States, 2HeartVista, Los Altos, CA, United States


Hyperpolarized 13C-labeled compound is an emerging technique in biomedical imaging to non-invasively detect metabolic processes and has been translated in clinical for cancer and cardiac metabolism studies. However, hyperpolarized MRI signal is limited by high spatial and temporal resolution and high SNR. This work describes a novel rotated Echo-planar imaging (EPI) trajectory with a half scan acquisition that shortens echo time to reduce the T2* effect in metabolic imaging. Compared to the standard full sampled EPI trajectory, the proposed trajectory has the advantage of gaining higher signal intensity, and is less sensitive to motion artifacts, distortion artifacts and aliasing artifacts.

This abstract and the presentation materials are available to members only; a login is required.

Join Here