Pyruvate metabolism in skeletal muscle plays an essential role for energy production and development of muscular dystrophy (MD). However, investigation of the metabolism of MD has been focused on myocardium due to its vital importance, rather than skeletal muscle. This study presents preliminary results that demonstrate the feasibility of assessing altered pyruvate metabolism in the skeletal muscle of Becker MD patient with hyperpolarized [1-13C]pyruvate. In parallel, the metabolic profile of MD skeletal muscle was analyzed by NMR using a Duchenne MD mouse model after [U-13C3]pyruvate infusion. This study indicates that pyruvate metabolism is altered in skeletal muscle with MD.
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