We describe recent advances with Parahydrogen Induced Polarization (PHIP) to establish easy-to-use, inexpensive hyperpolarizers with potential for translation into preclinical and clinical practice. We show that more than 10% polarization of [1-13C]-Pyruvate can be established by SABRE-SHEATH. With those polarization levels, we demonstrate hyperpolarized MRI at 1.5 T of a cryogen-free MRI system. We also describe a PHIP reactor that provides continuous hyperpolarization and achieves RASER (Radio-wave Amplification by Stimulated Emission of Radiation), which gives 100% background free, high resolution MR signals. By combining PHIP methods with low-field MRI, an affordable yet highly sensitive molecular imaging approach may emerge.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords