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Abstract #3570

Recent advances in parahydrogen induced polarization for hyperpolarized low-field MRI

Thomas Theis1, Patrick TomHon1, Soeren Lehmkuhl1, Boyd Goodson2, Yi-Fen Yen3, Matthew Rosen3, and Eduard Chekmenev4
1Chemistry, North Carolina State University, Raleigh, NC, United States, 2Chemistry, Southern Illinois University, Carbondale, IL, United States, 3Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, 4Chemistry, Wayne State University, Detroit, MI, United States


We describe recent advances with Parahydrogen Induced Polarization (PHIP) to establish easy-to-use, inexpensive hyperpolarizers with potential for translation into preclinical and clinical practice. We show that more than 10% polarization of [1-13C]-Pyruvate can be established by SABRE-SHEATH. With those polarization levels, we demonstrate hyperpolarized MRI at 1.5 T of a cryogen-free MRI system. We also describe a PHIP reactor that provides continuous hyperpolarization and achieves RASER (Radio-wave Amplification by Stimulated Emission of Radiation), which gives 100% background free, high resolution MR signals. By combining PHIP methods with low-field MRI, an affordable yet highly sensitive molecular imaging approach may emerge.

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