Abstract #3571

Mapping Pyruvate-to-Lactate Rate Constants in Hyperpolarized Data with bSSFP Acquisitions

Sule Sahin^1,2, Nicholas Dwork¹, Shuyu Tang³, Xiaoxi Liu¹, Zhen Jane Wang¹, and Peder E.Z. Larson¹

¹Radiology, University of California, San Francisco, San Francisco, CA, United States, ²UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley, CA, United States, ³HeartVista, Los Altos, CA, United States

Synopsis

Using a metabolite-specific bSSFP sequence for hyperpolarized [1-¹³C]pyruvate MRI has been shown to increase SNR significantly, yet specialized k_PL methods have not been developed for this sequence. A k_PL fitting method for bSSFP lactate acquisition was developed and voxel-wise k_PL fitting was performed on four renal cell carcinoma subjects. The k_PL values and maps were compared to and showed agreement with lactate over pyruvate AUC ratio maps and spoiled gradient echo k_PL values and maps.

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