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Abstract #3571

Mapping Pyruvate-to-Lactate Rate Constants in Hyperpolarized Data with bSSFP Acquisitions

Sule Sahin1,2, Nicholas Dwork1, Shuyu Tang3, Xiaoxi Liu1, Zhen Jane Wang1, and Peder E.Z. Larson1
1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley, CA, United States, 3HeartVista, Los Altos, CA, United States


Using a metabolite-specific bSSFP sequence for hyperpolarized [1-13C]pyruvate MRI has been shown to increase SNR significantly, yet specialized kPL methods have not been developed for this sequence. A kPL fitting method for bSSFP lactate acquisition was developed and voxel-wise kPL fitting was performed on four renal cell carcinoma subjects. The kPL values and maps were compared to and showed agreement with lactate over pyruvate AUC ratio maps and spoiled gradient echo kPL values and maps.

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